This Guide was originally published in 2001 as A Practical Guide to Containment: Greenhouse Research with Transgenic Plants and Microbes and primarily addressed containment of transgenic [genetically engineered (GE) or genetically modified (GM)] plants or plant-associated organisms. Researchers, facility managers, and regulators have subsequently encouraged the authors to expand this Guide beyond containment of solely transgenic organisms. Therefore, the reader will find new information on containment strategies for research with exotics (non-native invasive species), pathogens, insects, GE plant-manufactured pharmaceuticals and industrial compounds, and high containment for quarantined organisms, including those included on the Select Agent list. Material was obtained from many individuals, primarily those acknowledged on page v, as well as from regulatory agencies, the literature, personal experience gained from facility planning and construction, and shared 'lessons learned' from the research community.

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